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. 2012 Dec 24;110(3):E221–E230. doi: 10.1073/pnas.1208573110

Fig. 5.

Fig. 5.

TRAJ use with TRAV13 in Tg4 CTLA-4WT and Tg4 CTLA-4KO thymocytes. To determine TRAJ use combined with TRAV13 in CD4SP thymocytes, we analyzed 2.6 million sequences from CTLA-4WT Tconv cells, 5.2 million sequences from CTLA-4KO Tconv cells, 4.2 million sequences from CTLA-4WT Treg cells, and 5.2 million sequences from CTLA-4KO Treg cells. (A) Percentage of functional TRAJ regions used at least one time within the millions of sequences analyzed. (B) Percentage of functional TRAJ regions used that were in frame. (C) Comparison of relative frequency of each functional, in-frame TRAJ region used with TRAV13 in CTLA-4WT and CTLA-4KO Tconv and Treg cells. (D) Graphic representation of relative use of functional, in-frame TRAJ regions used with TRAV13 that make up at least 5% of the total found in either cell type.