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. 2012 Dec 31;110(3):972–977. doi: 10.1073/pnas.1221055110

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Fig. 3. — Metformin inhibits the inflammatory response in CSCs. (A) Heat map representation of mRNA levels of the indicated inflammatory genes. (B) Lin28B mRNA levels. (C) VEGF levels in NSCCs or CSCs derived from ER-Src transformed cells treated with metformin. (D) Western blot analyses of the indicated proteins in cytosolic and nuclear fractions of CD44⁺ and CD44⁻ ER-Src cells treated with metformin. TBP and LDH protein levels were used as loading controls. (E) STAT3 phosphorylation levels in NSCCs and CSCs derived from four human breast cancer tissues (pt 1–4).