Horizontal transfers. This is a representation of the least number of subtree prune and regrafts (SPR) required to turn the control tree built from protein orthologs (A), into the tree built from the BovB sequences (J) through intermediates B–I. The movement that corresponds to the SPR in the next tree is shown by the arrow and the SPR that made the current tree is shown in red. D, Danio rerio; Eq, Equus caballus; Mo, Monotremata; Ec, Echinops telfairi; Lo, Loxodonta africana; Pr, Procavia capensis; Ig, Iguanidae; Me, Metatheria; Ag, Agamidae; Ru, Ruminantia; Bt, Bothriocroton hydrosauri; Sc, Scincidae; Ge, Gekkonidae; Am, Amblyomma limbatum; Se, Serpentes; Bm, Bombyx mori; and St, Strongylocentrotus purpuratus.