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Treatment with FK866 does not reduce infarct size in a Langendorff model without circulating leukocytes. Vehicle or FK866 (5 μg/ml) was added to the perfusion medium 5 min after ischemia onset. Data are expressed as scattered plots (mean±SEM, n=7–8 per group). (A) Quantification of area at risk (AAR) per ventricle surface (V) after 2 h of reperfusion; p: N.S. (not significant). (B) Quantification of infarct size (I) per V after 2 h of reperfusion; p: N.S. (not significant).
