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. 2012 Dec 26;190(3):1048–1055. doi: 10.4049/jimmunol.1202455

FIGURE 6.

FIGURE 6.

Selective depletion of IM has no effect on the PPS14- or PC-specific IgG responses to soluble pneumococcal conjugate vaccines (PPS14-PspA plus CPS-PspA). CD11b-DTR BM-chimeric mice (seven mice per group) with or without injection of DT 24 h earlier were injected i.p. with PPS14-PspA (1 μg/mouse) in alum plus CpG-ODN. DT was administered every 2 to 3 d for the duration of the experiment. Mice were boosted with PPS14-PspA on day 14 in a similar manner. Serum titers of Ag-specific IgM and IgG were measured by ELISA. One of two representative experiments. *p ≤ 0.05.