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. 2012 Sep 9;125(2):273–288. doi: 10.1007/s00401-012-1043-z

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© The Author(s) 2012

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Fig. 6 — FUS and ubiquitin spinal cord pathology in hFUS mice. a–c FUS expression in the anterior horn of the spinal cord was increased in both (+/−) (b) and (+/+) (c) hFUS mice compared to their NTg littermates (a) (scale bar 50 μm). d A higher power image showing the presence of a FUS inclusion (arrow) in a large neuron of a hFUS (+/+) animal. (scale bar 20 μm). There was no evidence of inclusions in either hFUS (+/−) or NTg animals. e–g Abnormal granular ubiquitin was only present in a few large neurons of hFUS (+/+) (g) animals, with no significant staining in the anterior horn of the spinal cord of either NTg (e) or hFUS (+/−) (f) animals (scale bar 50 μm). h A higher power image showing rather diffuse, granular ubiquitin staining throughout two large neurons, with no obvious large inclusions visible (scale bar 20 μm). i Fluorescent labelling of HA-tagged FUS and ubiquitin in a neuron of the anterior horn of the spinal cord of a hFUS (+/+) mouse shows multiple small FUS inclusions in the cytoplasm of the cell with diffuse, low-level ubiquitin staining throughout the cytoplasm, but no evidence of HA-FUS and ubiqitin colocalisation (scale bar 5 μm)