TABLE 2.
Presence in Our Data Set of Previously Reported Human Genes Modulated by Radiation
| Radiation doses and times | 0 Gy
|
0.05 Gy
|
5 Gy
|
||||||
|---|---|---|---|---|---|---|---|---|---|
| 2 h | 8 h | 30 h | 2 h | 8 h | 30 h | 2 h | 8 h | 30 h | |
| Gene symbol and category | |||||||||
| Apoptosis | |||||||||
| BAXa | / | / | / | / | / | / | / | / | / |
| BBC3c | / | / | / | / | / | / | / | / | / |
| TNFRSF10Bd | / | / | / | / | / | / | / | / | / |
| TNFSF9b | / | / | TNFSF 14 and 15 up | / | / | TNFSF 15 down | / | / | TNFSF 15 down |
| Cell cycle/Proliferation | |||||||||
| CDKN1Aa,c,f,g,h | / | / | down | / | / | / | / | up | up |
| CCNG1d | / | / | / | / | / | / | / | / | up |
| PCNAa | / | / | / | / | / | / | / | / | / |
| DNA damage/Repair | |||||||||
| DDB2a,g | / | / | / | / | / | / | / | / | / |
| GADD45a,g,h | / | / | / | / | / | / | / | / | / |
| UBE2Be | / | / | / | / | / | / | / | / | / |
| Energy/Translation/Degradation | |||||||||
| FDXRc | / | / | / | / | / | / | / | / | / |
| FHL2d | / | / | / | / | / | / | / | / | / |
| GARSe* | / | / | / | / | / | / | / | / | / |
| SESN1c | / | / | / | / | / | / | / | up | up |
| Immune response | |||||||||
| CXC L10d | / | / | / | / | / | / | / | / | / |
| FCGR1Ag | / | / | / | / | / | / | / | / | / |
| IFNGb | / | / | / | / | / | / | / | / | / |
| Transcription modulators | |||||||||
| EGR1b,f | / | / | / | / | / | / | / | / | / |
| EGR4b | / | / | / | / | / | / | / | / | / |
| JUNb | / | / | / | / | / | / | / | / | / |
| SPOPe | / | / | / | / | / | / | / | / | / |
| TXNLe | / | / | / | / | / | / | / | / | / |
| Zinc finger proteins | |||||||||
| PHF10e | / | / | / | / | / | PHF13 up | / | / | PHF13 up |
| PHPT13c | / | / | / | / | / | / | / | / | / |
Genes induced in CD4+ lymphocytes 24 h postexposure to 0.5 Gy ex vivo (19).
Genes upregulated in PBL after 15 min ex vivo irradiation of human whole blood with 1 and 4 Gy of X rays (16).
Genes induced in PBL in response to ex vivo irradiation with 0.5, 2, 5 and 8 Gy of γ rays, after 6 and 24 h postexposure (12).
Genes upregulated in PBL 12 h after ex vivo exposure to 1 Gy (14).
Genes upregulated in primary normal keratinocytes after irradiation with 0.01 or 2 Gy γ rays (18).
Genes upregulated in G1-arrested primary normal fibroblasts in response to 4 Gy (23).
Genes upregulated in whole blood at 6 and 24 h after total body irradiation with single and multiple 1.5-Gy X-ray doses (10).
Genes induced in ML-1 cells in response to 0.02–0.5 Gy of γ rays after 1 to 4 h postexposure (40).