TABLE 4.
Unique and Specific Genes Modulated in Human Skin at 2 and 8 h after Ex Vivo Exposure to Low or High Radiation Doses
| Gene symbol | Regulation | Name |
|---|---|---|
| Specific genes responsive to 0.05 Gy at 2 and 8 h postirradiation | ||
| At 2 h after exposure | ||
| PSORS1C2 | −1 | Psoriasis susceptibility 1 candidate 2 |
| NTN4 | −1 | Netrin 4 |
| RILPL2 | −1 | Rab interacting lysosomal protein-like 2 |
| NLRP3 | −1 | NLR family, pyrin domain containing 3 |
| At 8 h after exposure | ||
| PRDM1 | 1 | PR domain containing 1 with ZNF domain |
| Unique genes responsive to 0.05 Gy at 2 and 8 h postirradiation | ||
| None | ||
| Specific genes responsive to 5 Gy at 2 and 8 h postirradiation | ||
| At 2 h after exposure | ||
| ACTB | 1 | β actin |
| ATN1 | 1 | Atrophin 1 |
| COX7A2 | 1 | Cytochrome c oxidase subunit VII a polypeptide 2 |
| LBH | 1 | Limb bud and heart development |
| NDUFA1 | 1 | NADH dehydrogenase 1 α complex |
| ZNF581 | 1 | Zinc finger protein 581 |
| At 8 h after exposure | ||
| A1CF | −1 | APOBEC1 complementation factor |
| AGTRAP | 1 | Angiotensin II receptor-associated protein |
| BRSK1 | −1 | BR serine/threonine kinase 1 |
| C17ORF68 | 1 | Chromosome 17 open reading frame 68 |
| C18ORF56 | 1 | Chromosome 18 open reading frame 56 |
| C1ORF110 | −1 | Chromosome 10 open reading frame 110 |
| C8A | −1 | Complement component 8, α polypeptide |
| CABLES1 | 1 | Cdk5 and Abl enzyme substrate 1 |
| CAMK2B | −1 | Calcium/calmodulin dependent protein kinase 2β |
| CBLC | 1 | Cas-Br-M ecotropic retroviral transforming sequence C |
| CCDC149 | −1 | Coiled coil domain containing 149 |
| CDIPT | 1 | CDP diaglycerol inositol 3 phosphatidyltransferase |
| CDKN1A | 1 | Cyclin dependent kinase inhibitor 1A (p21) |
| CSAG3 | −1 | CSA family member 3 |
| CYR61 | −1 | Cysteine rich angiogenic inducer 61 |
| DGKQ | 1 | Diaglycerol kinase theta |
| DNAJB1 | −1 | DNA 5 homolog subfamily B, member 1 |
| FAM104B | −1 | Family with sequence similarity 104, member B |
| FAM82A | −1 | Family with sequence similarity 82, member A1 |
| FLVCR2 | 1 | Feline leukemia virus subgroup C cellular receptor family, member 2 |
| GRM3 | −1 | Glutamate receptor, metabotropic 3 |
| HPS6 | 1 | Hermansky-Pudlak syndrome 6 |
| IL1RAPL1 | −1 | Interleukin 1 receptor accessory protein-like 1 |
| JMJD4 | 1 | Jumonji containing domain 4 |
| KLRB1 | −1 | Killer cell lectin-like receptor subfamily B, member 1 |
| LILRB3 | −1 | Leukocyte immunoglobin-like receptor family B, member 3 |
| NCRNA268 | −1 | Noncoding RNA 268 |
| LOC441426 | −1 | Non-protein coding RNA 268 |
| MGC10997 | −1 | Protein pseudogene MGC10997 |
| MOCOS | 1 | Molybdenum cofactor sulfurase |
| MRPL27 | 1 | Mitochondrial ribosomal protein L27 |
| NECAP1 | −1 | NECAP endocytosis associated 1 |
| NOL10 | −1 | Nucleolar protein 10 |
| NR2E3 | −1 | Nuclear receptor subfamily 2, group E, member 3 |
| ODZ3 | −1 | ODZ, odd Oz/ten-m homolog 3 |
| ORAI1 | −1 | ORAI calcium release-activated calcium modulator 1 |
| PACSIN3 | 1 | Protein kinase C and casein substrate in neurons 3 |
| PARC | 1 | Cullin 9 |
| PEX16 | 1 | Peroxisomal biogenesis factor 16 |
| PIGQ | 1 | Phophatidylinositol glycan anchor biosynthesis class Q |
| PKP3 | 1 | Plakophilin 3 |
| PNPO | 1 | Pyridoxamine 5′ phosphate oxidase |
| POLR2C | 1 | RNA II polymerase DNA directed polypeptide C |
| POMGTN1 | 1 | Protein O-linked mannose β 1,2 acetylglucosaminytransferase |
| PPARGC1A | −1 | Peroxisome proliferator-associated receptor γ coactivator 1 α |
| PTCD1 | 1 | Pentatricopeptide repeat domain 1 |
| RBM45 | 1 | RNA binding motif 45 |
| RCAN2 | −1 | Regulator of calcineurin 2 |
| RGS17 | −1 | Regulator of G protein signaling 17 |
| RNF165 | −1 | Ring finger protein 165 |
| RPL36 | −1 | Ribosomal protein L36 |
| SCAP | 1 | SREBF chaperone |
| SCN2A | −1 | Sodium channel, voltage gated, type II, α subunit |
| SCRIB | 1 | Scribbled homolog |
| SESN1 | 1 | Sestrin 1 |
| SKI | −1 | v-ski sarcoma viral oncogene homolog |
| SLC1A3 | 1 | Solute carrier family 1, member 3 |
| SORBS1 | −1 | Sorbin and SH3 domain containing 1 |
| SRA1 | 1 | Steroid receptor RNA activator 1 |
| STC1 | −1 | Stanniocalcin 1 |
| SUPT6H | 1 | Suppressor of Ty 6 homolg |
| TGIF2 | 1 | TGFB induced factor homebox 2 |
| TLE1 | 1 | Transducing-like enhancer of split 1 |
| TTF2 | 1 | Transcription termination factor RNA polymerase II |
| UCRC | −1 | Ubiquinol cytochrome c reductase, complex III subunit X |
| UGT2B7 | −1 | UDP glucuronosyltransferase 2 family, polypeptide B7 |
| WAC | −1 | WW domain containing adaptor with coiled-coil |
| WDR74 | 1 | WD repeat domain 74 |
| ZBTB9 | 1 | Zinc finger and BTB domain containing 9 |
| ZC3H10 | 1 | Zinc finger CCH-type containing 10 |
| ZFYVE27 | 1 | Zinc finger FYVE domain containing 27 |
| ZNF524 | 1 | Zinc finger protein 524 |
| Unique genes responsive to 5 Gy at 2 and 8h postirradiation | ||
| At 2 h after exposure | ||
| None | ||
| At 8 h after exposure | ||
| AGBL4 | −1 | ATP/GTP binding protein like 4 |
| KCBN2 | −1 | Potassium voltage gated channel, Shab related, member 2 |
| NUP153 | −1 | Nucleoporin 153 KDa |
| SLC29A1 | −1 | Solute carrier family 29, member 1 |
| TXNRD1 | −1 | Thioredoxin reductase 1 |