Table 3.
Occurrence of preS deletion mutants in serial samples during ADV treatment
|
Patients (CH) |
Start |
End |
||
|---|---|---|---|---|
| PCR direct sequencing | PCR direct sequencing | Clone sequencing | ||
|
ADV |
1 |
N |
D |
aa 65–78 (peS1), |
|
(+) |
(Jan 24, 2005) |
(Mar 22, 2005) |
3/5 clones |
|
| |
2 |
N |
D |
aa 132–141 (preS2), |
| |
(Dec 15, 2004) |
(Mar 21, 2005) |
2/5 clones |
|
|
ADV |
3 |
N |
N |
- |
|
(−) |
(Dec 17, 2004) |
(Feb 28, 2005) |
||
| |
4 |
N |
N |
- |
| (Jan 14, 2005) | (Jun 7, 2005) | |||
N, no deletion detected; D, deletion detected.