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. Author manuscript; available in PMC: 2013 Jan 19.
Published in final edited form as: N Engl J Med. 2010 Jun 5;363(8):711–723. doi: 10.1056/NEJMoa1003466

Figure 2. Subgroup Analyses of Overall Survival.

Figure 2

The prespecified analyses of overall survival among subgroups of patients, as defined by baseline demographic characteristics and stratification factors (metastasis [M] stage, classified according to the tumor–node–metastasis [TNM] categorization for melanoma of the American Joint Committee on Cancer; and receipt or nonreceipt of interleukin-2 therapy), showed that hazard ratios were lower than 1 (indicating a lower risk of death) for each subgroup in the ipilimumab (Ipi)-plus-glycoprotein 100 (gp100) group as compared with the gp100-alone group (Panel A) and for each subgroup in the ipilimumab-alone group as compared with the gp100-alone group (Panel B). Hazard ratios were estimated with the use of unstratified Cox proportional-hazards models. Horizontal lines represent 95% confidence intervals. LDH denotes lactate dehydrogenase, and ULN the upper limit of the normal range.