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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Ann Surg. 2012 Feb;255(2):379–385. doi: 10.1097/SLA.0b013e318235d9e6

Figure 3. Systemic Activation of the protein C pathway is associated with the inactivation of factors Va and VIIIa and derepression of fibrinolysis in trauma patients.

Figure 3

Patients were divided into quartiles based on plasma levels of activated protein C. Patients with the highest activation of protein C in the plasma (highest quartile) had a coagulopathy caused by deactivation of factor Va (Panel A) and factor VIIIa (Panel B). In addition, patients with the highest plasma level of aPC had a derepression of the fibrinolysis, as evidenced by elevated tPA and d-Dimers (Panel C&D).