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. Author manuscript; available in PMC: 2013 Jan 20.
Published in final edited form as: Nature. 2012 Nov 14;491(7425):594–598. doi: 10.1038/nature11673

Figure 2. Aberrant light impairs hippocampal learning, LTP, and recognition memory.

Figure 2

A. Experimental paradigm for the MWM. B. T7 mice showed impaired learning (n= 21 per group, pinteraction=0.041, Bonferroni post-test p<0.01 days 2 and 4). C. T7 mice show no significant preference for the target quadrant (T24: n=9, p=0.011; T7: n=9, p=0.25). Dotted line indicates chance (25%). D. Mice housed in the T24 cycle showed an increased latency in a reversal trial, whereas, T7 housed mice show a similar latency to the acqusition phase (n= 9 per group, pinteraction<0.0003, Bonferroni post-test p<0.01 days 15 and 16). E and F. T24 and T7 mice have similar basal synaptic release properties (pinteraction=0.7256) (n= 5 per group) (Fiber volley: pinteraction=0.984, Slope: p>0.1). G–I. T7 mice showed LTP deficits (n= 5 per group, 1 TBS: pinteraction<0.01; 4 TBS: pinteraction<0.01) (G and H) but no difference in LTD (I). J. T7 mice showed deficit in novel object recognition (T24: n=24, p=0.0057; T7: n=24, p=0.1773). *p< 0.05. Error bar indicates SEM.