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. Author manuscript; available in PMC: 2013 Jan 20.
Published in final edited form as: Nature. 2012 Nov 14;491(7425):594–598. doi: 10.1038/nature11673

Figure 3. Chronic antidepressant administration rescues learning.

Figure 3

A. Timeline for fluoxetine administration and testing B. Chronic fluoxetine reduced T7 immobility time in the FST (n=10 per group, pinteraction=0.0092, Bonferoni posttest p<0.001 T24 vs T7 vehicle) C. T7 mice treated with fluoxetine showed restored novel object preference (T24vehicle: n=9, p=0.03; T24fluoxetine: n=9, p=0.048; T7vehicle: n=10, p=0.77; T7fluoxetine: n=10, p=0.04). D. Chronic fluoxetine rescued the T7-induced LTP deficit (n=5,4; pinteraction<0.0001). E. Chronic fluoxetine decreased corticosterone levels in T7 mice (n=5–8 per time point). T7 corticosterone levels are plotted for comparison. (pinteraction=0.0053, Bonferroni post-test p<0.0001 CT13 and p<0.001 CT19) ****p<0.0001, ***p<0.001, *p< 0.05. Error bar indicates SEM.