Table 1.

Reaction and kinetic parameters associated with the Ras immuno-spin trapping pathways illustrated in Figure 2

Reaction Number	Reaction	kfor	krev	K	Ref.
1	·NO2 + Ras-SH → Ras-S·	≥ 2 × 107 M−1·s−1a	n/a	n/a	[15,20]
2	·NO2 + ·NO ↔ N2O3	1.1 × 109 M−1 ·s−1	4.3 × 106 s−1	2.6 × 102 M−1	[20,21]
3	·NO2 + ·NO2 ↔ N2O4	4.5 × 108 M−1·s−1	--	7 × 104 M−1	[21-23]
4	N2O3 + Ras-SH → Ras-SNO	1.6 × 103 M−1·s−1a	n/a	n/a	[15,24]
5	Ras-S· + ·NO → Ras-SNO	3 × 109 M−1·s−1a	n/a	n/a	[25,26]
6	Ras-S· + DMPO → Ras-S-DMPO·	2.6 × 108 M−1·s−1a	n/a	n/a	[15,27]
7	Ras-S· + O2 ↔ Ras-SOO·	2.2 × 109 M−1·s−1a	6.2 × 105 s−1a	3.3 × 103 M−1a	[28,29]
8	Ras-SOO· → Ras-SO2	2 × 103 s−1a	n/a	n/a	[28]

^aKinetic rates reported are based on reactions using reduced glutathione (GSH).