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Model of Ras activation by •NO-mediated processes in pancreatic cancer. Pancreatic cancer growth and maintenance is dependent, in part, on activation of eNOS by oncogenic K-ras. NO subsequently activates wild-type H-ras and N-ras. H- and N-ras contribute to the effects of oncogenic K-ras, which include anchorage-independent growth and tumor formation in mice. N-ras and H-ras may also activate PI3K/Akt, which would constitute a positive feedback activation of the PI3K pathway.
