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. Author manuscript; available in PMC: 2014 Jan 7.
Published in final edited form as: Mol Pharm. 2012 Dec 24;10(1):77–89. doi: 10.1021/mp3005148

Figure 3. MSCs as gene delivery vehicles to promote human islet transplantation in streptozotocin induced diabetic mice.

Figure 3

(A) Overexpression of hepatocyte growth factor by Adv-hHGF-hIL-Ra transduced MSCs. (B) Overexpression of human interleukin 1 receptor antagonist by Adv-hHGF-hIL-Ra transduced MSCs. (C) Genetically modified MSCs enhanced the islets revascularization and prevented cytokines injury and inflammatory reactions as evident in prolonged normoglycemia in islets + adenovirus transduced MSCs group. (D) Transduction of MSCs with adenovirus did not affect differentiation ability and secretion of growth factors as measured by levels of VEGF and IL-10