Fig. 3.

Hypothyroidism diminished stereotypic behavior in cocaine-administered mice. After 14 days of once per day cocaine injection (15 mg/kg), mice were withdrawn from cocaine for 48 h followed by a challenge injection (15 mg/kg). Stereotypic behavior was assessed and cocaine-treated mice displayed significantly greater activity at 30 min post-challenge than control mice (*p < 0.01). Stereotypic behavior in hypothyroid mice administered cocaine was significantly diminished compared with euthyroid cocaine-treated mice (**p < 0.05). Data were analyzed by one-way ANOVA with Newman–Keuls multiple comparison post hoc test. n ≥ 6 mice per group.