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. Author manuscript; available in PMC: 2013 Nov 27.
Published in final edited form as: Life Sci. 2012 Aug 22;91(21-22):1070–1076. doi: 10.1016/j.lfs.2012.08.020

Figure 1. Stress and topical treatment with nicotine or α-bungarotoxin (Bung) promotes epidermal barrier disruption and reduces barrier recovery following barrier disruption.

Figure 1

Transepidermal water loss (TEWL) was measured on the mouse dorsum (n=10–18/group) following three days of psychological stress in the presence or absence of Bung (A), or in unstressed mice treated topically with vehicle, nicotine, or Bung (B). TEWL measurements taken 3, 6 and 24 hours following barrier disruption via tape stripping were used to assess barrier recovery following stress (C) or nicotine treatment (D) +/− Bung. All comparisons represent differences from unstressed, vehicle (A, C) or vehicle alone (B, D) within the same time-point by One-way ANOVA with Dunnett’s multiple comparison post-test where *p < 0.05 was considered significant. #p = 0.06