Table 2.
Antibacterial Properties of Rubrolides 1-6.
| Compound | MRSA | S. epidermidis | E. faecalis | E. coli |
|---|---|---|---|---|
|
|
||||
| aIC50 μM (SEM) | aIC50 μM (SEM) | Percent growth inhibition at 100 μg/mL (SEM) | ||
|
|
||||
| 3″-Bromorubrolide F (1) | 256 (1.3) | 98 (1.2) | 43 (8.3) | 22 (1.9) |
| 3′-Bromorubrolide E (2) | 82 (1.4) | 38 (1.7) | 16 (14.1) | 0 (26.2) |
| 3′-Bromorubrolide F (3) | 360 (1.3) | 42 (1.2) | 2 (3.1) | 14 (14.4) |
| 3′, 3″-Dibromorubrolide E (4) | 89 (1.3) | 28 (1.4) | 2 (12.9) | 25 (4.6) |
| Rubrolide E (5) | 105 (1.5) | 21 (1.5) | 89 (3.6) | 16 (2.8) |
| Rubrolide F (6) | 1006 (1.3) | 79 (1.1) | 47 (10.4) | 15 (5.5) |
a
IC50 values represent the mean of 3 independent experiments, derived using nonlinear regression analysis; SEM = standard error of the mean