Figure 7.

A proposed model for retinal stem cell (RSC) cell-off-origin and Hes4 function during embryonic retinogenesis. (A): Schema highlighting the dynamics of Hes4 expression during retinogenesis. Adult RSCs likely originate from the most dorsal Hes4-expressing part of the optic vesicle (red dotted lines). (B): Schematic illustration of Hes4 regulation and function in the presumptive adult RSCs. Abbreviations: CMZ, ciliary marginal zone; GCL, ganglion cell layer; INL/ONL: inner/outer nuclear layer; NR, neural retina; RPE, retinal pigmented epithelium.