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. Author manuscript; available in PMC: 2014 Jan 27.
Published in final edited form as: Transplantation. 2013 Jan 27;95(2):293–300. doi: 10.1097/TP.0b013e3182772244

Figure 2. Loss of CD4+CD25+Foxp3+ regulatory T cells and Induction of autoAbs to pulmonary self antigens, KAT and Col-V following ligation of anti-MHC class I Abs.

Figure 2

(A) Flow cytometric analysis of the frequency of Tregs in the lungs of anti-H2kb treated mice revealed a significant decline in the both IL-17A−/− (anti-H2kb- 7.31; C1.18.4–13.72) and WT mice (anti-H2kb5.01; C1.18.4–15.15) compared to control mice. However, the percentage decline in the frequency of Tregs was higher in WT (10.14%) compared to IL-17A−/− (6.41%) treated with anti-H2kb. (B) Levels of antibodies against the self antigens KAT and Col-V in BAL were measured by ELISA. The titers of the antibodies are presented as mean ± SD (µg/ml). A significant increase in the titer of Abs to both KAT and Col-V was observed in anti-H2kb treated IL-17A−/− and WT mice.