Figure 1.

Female mice, but not male litter mates show enhanced Th2-associated immunity in susceptible or slow responder strains. (A) AKR and IL-4KO BALB/c mice were infected with T. muris eggs and adult worm burdens assessed at day 14, 21 or 28 and 35 p.i. (B) MLNC from AKR mice were restimulated with T. muris E/S antigen after 40 days p.i. and cytokine production assessed via CBA. (C) Caecal histology of infected male and female AKR mice was compared at day 40 p.i. Data represent two independent experiments of n=10±SEM. ^*p≤0.05, ^**p≤0.01, ^***p≤0.001, Kruskal Wallis ANOVA. Average naïve levels indicated by red lines.