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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Biochem J. 2012 Apr 1;443(1):259–266. doi: 10.1042/BJ20111994

Figure 7. Disruption of caveolae significantly decreases the TF-fVIIa inhibitory activity of endogenous TFPI.

Figure 7

Maximum amount of fXa (nM) generated by α-cyclodextrin (α-CD) or methyl-β-cyclodextrin (M-β-CD) treated cells. A) EA.hy926 cells; B) CHO cells transfected with human TFPIβ; C) HUVEC. Equivalent cell concentrations of approximately 300 µg/mL total cellular protein were used for all experiments; mean ± SD, n=4 for HUVEC or n=8 for EA.hy926 and CHO-TFPIβ. The assay was performed with cells in suspension. ** - p < 0.01 vs. α-CD control of the same cell type; *** - p < 0.001 vs. α-CD control of the same cell type.