Table 2.
Real-Time Quantitative Reverse Transcription–Polymerase Chain Reaction Data on Expression of mRNA for Selected Growth Factors, Cytokines, and Chemokines Isolated from Highly Purified Umbilical Cord Blood-Derived CD133+ Cells and CD133+ Cell-Derived Microvesicles—Compared to mRNA Isolated from Umbilical Cord Blood Mononuclear Cells (Shown as Fold Differences)
| mRNA for | CD133+ | MV CD133+ |
|---|---|---|
| FLT-3 | + | ++ |
| SCF | ++ | ++ |
| IGF-I | ++ | +++ |
| VEGF | ++ | ++ |
| FGF-2 | ++ | +++ |
| HGF | + | + |
| IL-1β | − | − |
| IL-16 | ++ | ++ |
| IL-8 | +++ | +++ |
| TNF-α | ++++ | ++++ |
| TNF-β | + | ++ |
| IFN-γ | − | − |
| TGF-β | + | ++ |
| MIF | ++++ | ++++ |
| RANTES | +++ | +++ |
| IP-10 | + | + |
| SDF-1 | − | − |
| MIP-1α | − | − |
−, < 1-fold increase; +, < 10-fold increase; ++, < 100-fold increase; +++, < 1,000-fold increase; ++++, > 1,000-fold increase compared to umbilical cord blood mononuclear cells; MV, microvesicle; MIP-1α, macrophage inflammatory protein-1α.