FIG. 1.

HUCBC infusion reverses working memory deficits in PSAPP transgenic mice. PSAPP mice and WT littermates were treated with a monthly HUCBC injection of 33×10⁶ cells/kg per mouse or 3.3 mL PBS/kg per mouse for 6 (a–c) or 10 months (d–f), followed by neurocognitive testing in a 2-day version of the radial-arm water maze (RAWM). In overall working memory performance, WT littermates/PBS, WT littermates/HUCBC, and PSAPP/HUCBC mice reveal significantly lower escape latencies than PSAPP/PBS mice (P<0.05). HUCBC, human umbilical cord blood cell; WT, wild-type; PBS, phosphate buffered saline. Color images available online at www.liebertpub.com/scd