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. 2013 Jan 14;210(1):31–40. doi: 10.1084/jem.20121076

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© 2013 Bergmann et al.

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Figure 3. — Overexpression of antiapoptotic BCL2 in Sppl2a^−/− mice rescues accumulation of mature B cells. (A) Representative flow cytometric plots of lymphocytes in the spleen from mice of the indicated Sppl2a and Vav-Bcl2 genotypes. Pregates for plots are indicated above the columns. (B) Number of B cells of the indicated subsets in spleens from Sppl2a^+/+ and Sppl2a^−/− mice, either transgenic for Vav-Bcl2 or not. Bars show mean, and each symbol is a single mouse. (C) Representative flow cytometric plots of CD62L and CD93 expression on B cells from subcutaneous LNs in Vav-Bcl2 transgenic mice of the indicated genotype. Overlay of flow cytometric histograms for B220, IgM, IgD, BAFFR, and CD23 cell surface expression on CD62L^highCD93^low mature B cells in spleen (top) or LNs (bottom) from Sppl2a^+/+ (shaded gray) and Sppl2a^−/− (black line) mice. Numbers in the plots indicate geometric mean fluorescence intensity for Sppl2a^+/+ (gray; top) and Sppl2a^−/− cells (black; bottom). Data are representative of one to three experiments with three to four mice per group (A and C) or combined from four experiments (B).