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. 2013 Jan 14;210(1):125–142. doi: 10.1084/jem.20120525

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© 2013 Andrews et al.

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Figure 3. — Receptor editing to endogenous LCs reduces the autoreactivity of the BCR. (A–C) The level of autoreactivity of mAbs cloned from mature B cells in Ig^Vκ4/h mice that were allelically included mCκ⁺hCκ⁺ (A) or mCκ⁻hCκ⁺ excluded (C). A total of 88 mAbs from 44 allelically included cells (sorted from three Ig^Vκ4/h mice) and 12 mAbs from allelically excluded cells were tested. Analysis by mouse for allelically included cells is provided in B. Shown is total binding to HEp-2 cells and dsDNA by ELISA and to HEp-2 cells by IMF as described for Fig 2. Statistics were calculated by the paired Student’s t tests. (D and E) The level of autoreactivity of mAbs cloned from mature B cells in Ig^αhel/h mice that were allelically included mCκ⁺hCκ⁺ (D) or mCκ⁻hCκ⁺ excluded (E). mAbs from a total of 13 allelically included cells and 9 allelically excluded cells were tested. Binding to autoantigens was performed and analyzed as in A–C. (A–E) Red lines indicated the mean AUC.