Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Jan 14;210(1):125–142. doi: 10.1084/jem.20120525

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2013 Andrews et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 8. — Secondary tolerance in Igκ^Vκ4/h and Igκ^αhel/h mice. (A) Splenic naive FM B cells and IgG1/2⁺ isotype-switched cells were gated, and the percentage of cells in each population that expressed mCκ, hCκ, or λ was determined by flow cytometry. Mean with SD of nine mice from three independent experiments is shown. (B) mCκ or hCκ serum IgG levels were determined by ELISA. Shown is the ratio of the OD values of hCκ relative to mCκ for each mouse. (C) IgG⁺ plasmablasts expressing the mCκ or hCκ allele in the spleen were detected by ELISPOT. Shown is the ratio of hCκ⁺ to mCκ⁺IgG⁺ antibody-secreting cells (ASC) for each mouse. (B and C) Horizontal lines indicate the mean.