Table 1.
Predicted targets of modulated miRNAs upon RABV infection involved in immune response pathways
miRNA | KEGG pathway | Target genes | Number of targets | Pvalue |
---|---|---|---|---|
mmu-miR-377 |
mmu04630: Jak-STAT signaling pathway |
CSF2RB2, EP300, JAK2, SOCS4, BCL2L |
5 |
0.01 |
mmu-miR-377 |
mmu04010: MAPK signaling pathway |
CACNA2D1, FASL, PPM1A, PPP3R1, RASA1, FLNC, PLA2G4A, SRF |
8 |
0.02 |
mmu-miR-377 |
mmu04060: Cytokine-cytokine receptor interaction |
CSF2RB2, FASL, ACVR2A, VEGFA, IL18RAP, KITL, PDGFRA, LTB |
8 |
0.001 |
mmu-miR-377 |
mmu04666: Fc gamma R-mediated phagocytosis |
WASF1, LIMK1, PRKCD, PLA2G4A, RPS6KB1 |
5 |
0.01 |
mmu-miR-377 |
mmu04520: Adherens junction |
WASF1, EP300, YES1, PVRL4, PTPRB, SMAD4 |
6 |
1.18E-06 |
mmu-miR-377 |
mmu04310: Wnt signaling pathway |
EP300, WNT5A, PPP3R1, FZD3, FZD4, AXIN1, BTRC, SMAD4, CUL1, DKK1 |
10 |
3.62E-04 |
mmu-miR-377 |
mmu04360: Axon guidance |
PPP3R1, RASA1, LIMK1, SEMA6A, SEMA3D |
5 |
0.001 |
mmu-miR-377 |
mmu04110: Cell cycle |
EP300, ESPL1, CDC26, CUL1 |
4 |
0.007 |
mmu-miR-377 |
mmu04350: TGF-beta signaling pathway |
EP300, ACVR2A, THBS1, PITX2, SMAD4, CUL1, LEFTY2, RPS6KB1 |
8 |
6.96E-06 |
mmu-miR-377 |
mmu04510: Focal adhesion |
MYLK2, XIAP, ITGA6, VEGFA, THBS1, PDGFRA, FLNC, LAMC1 |
8 |
0.018 |
mmu-miR-691 |
mmu04630: Jak-STAT signaling pathway |
GHR, SPRY2, TYK2, SPRED2, IL12A, CLCF1 |
6 |
0.01 |
mmu-miR-691 |
mmu04010: MAPK signaling pathway |
PLA2G10, MKNK2, MAPKAPK3, CACNB2, TGFBR2, DUSP9 |
5 |
0.02 |
mmu-miR-691 |
mmu04060: Cytokine-cytokine receptor interaction |
GHR, ACVR2A, BMP2, IL25, AMHR2, IL12A, TGFBR2, TNFSF14, CLCF1 |
9 |
0.001 |
mmu-miR-691 |
mmu04666:Fc gamma R-mediated phagocytosis |
LYN, INPP5D |
2 |
0.01 |
mmu-miR-691 |
mmu04520: Adherens junction |
CSNK2B, SRC, CDH1, TGFBR2 |
4 |
1.18E-06 |
mmu-miR-691 |
mmu04310: Wnt signaling pathway |
DKK2, CSNK2B, CAMK2G, CTBP2, VANGL1 |
5 |
3.62E-04 |
mmu-miR-691 |
mmu04360: Axon guidance |
PTK2, SEMA6D, ABLIM1, NRP1, PLXNA2, SRGAP3, SEMA5A |
7 |
0.001 |
mmu-miR-691 |
mmu04110: Cell cycle |
YWHAB, TFDP1 |
2 |
0.007 |
mmu-miR-691 |
mmu04350: TGF-beta signaling pathway |
ACVR2A, BMP2, THBS1, AMHR2, TFDP1, SP1, TGFBR2 |
7 |
6.96E-06 |
mmu-miR-691 |
mmu04510: Focal adhesion |
PTK2, IBSP, ITGA10, PGF, CAPN2, THBS1, SRC |
7 |
0.018 |
mmu-miR-1935 |
mmu04630: Jak-STAT signaling pathway |
LIFR, SPRY3 |
2 |
0.01 |
mmu-miR-1935 |
mmu04010: MAPK signaling pathway |
MAP3K12, FLNC, MAPT |
3 |
0.02 |
mmu-miR-1935 |
mmu04060: Cytokine-cytokine receptor interaction |
ACVR1, HGF, LIFR, CCR10 |
4 |
0.001 |
mmu-miR-1935 |
mmu04666: Fc gamma R-mediated phagocytosis |
MARCKS |
1 |
0.01 |
mmu-miR-1935 |
mmu04520: Adherens junction |
YES1, PVRL1 |
2 |
1.18E-06 |
mmu-miR-1935 |
mmu04310: Wnt signaling pathway |
NFAT5 |
1 |
3.62E-04 |
mmu-miR-1935 |
mmu04360: Axon guidance |
NFAT5, PLXNA4, SRGAP2, DCC |
4 |
0.001 |
mmu-miR-1935 |
mmu04110: Cell cycle |
STAG1, CDKN1C |
2 |
0.007 |
mmu-miR-1935 |
mmu04510: Focal adhesion |
FLNC |
1 |
0.018 |
mmu-miR-190 |
mmu04630: Jak-STAT signaling pathway |
IL6 |
1 |
0.01 |
mmu-miR-190 |
mmu04010: MAPK signaling pathway |
FASL, PLA2G6, BDNF, FGF14 |
4 |
0.02 |
mmu-miR-190 |
mmu04060: Cytokine-cytokine receptor interaction |
FASL, HGF, IL6, CXCL16 |
4 |
0.001 |
mmu-miR-190 |
mmu04666: Fc gamma R-mediated phagocytosis |
PLA2G6, ARPC5 |
2 |
0.01 |
mmu-miR-190 |
mmu04520: Adherens junction |
SMAD2, TJP1 |
2 |
1.18E-06 |
mmu-miR-190 |
mmu04310: Wnt signaling pathway |
SMAD2, PPP2R1B, ROCK1, PLCB1 |
4 |
3.62E-04 |
mmu-miR-190 |
mmu04360: Axon guidance |
EPHA1, ROCK1 |
2 |
0.001 |
mmu-miR-190 |
mmu04110: Cell cycle |
SMAD2, CHEK1, RBL1 |
3 |
0.007 |
mmu-miR-190 |
mmu04350: TGF-beta signaling pathway |
SMAD2, PPP2R1B, PITX2, ROCK1, RBL1 |
5 |
6.96E-06 |
mmu-miR-190 |
mmu04510: Focal adhesion |
CAPN2, HGF, ROCK1 |
3 |
0.018 |
mmu-miR-135a* |
mmu04630: Jak-STAT signaling pathway |
EP300,IL24,IFNAR2,IL12RB1,IFNG |
5 |
0.01 |
mmu-miR-135a* |
mmu04060: Cytokine-cytokine receptor interaction |
IL24,IFNAR2,IL12RB1,IFNG,CXCL16,CD40LG |
6 |
0.001 |
mmu-miR-135a* |
mmu04666: Fc gamma R-mediated phagocytosis |
NCF1 |
1 |
0.01 |
mmu-miR-135a* |
mmu04520: Adherens junction |
EP300, ACTN2 |
2 |
1.18E-06 |
mmu-miR-135a* |
mmu04310: Wnt signaling pathway |
EP300, WNT1, PPP2R1A |
3 |
3.62E-04 |
mmu-miR-135a* |
mmu04110: Cell cycle |
EP300, YWHAQ, ANAPC7 |
3 |
0.007 |
mmu-miR-135a* |
mmu04350: TGF-beta signaling pathway |
EP300, BMP4, IFNG, PPP2R1A |
4 |
6.96E-06 |
mmu-miR-135a* |
mmu04510: Focal adhesion |
PTEN, ITGA8, ACTN2 |
3 |
0.018 |
mmu-miR-290-5p |
mmu04630: Jak-STAT signaling pathway |
IL13RA1, IFNGR2, AKT1, CSF2RB |
4 |
0.01 |
mmu-miR-290-5p |
mmu04010: MAPK signaling pathway |
GADD45A, MAPKAPK3, MEF2C, MAP3K1, AKT1FGF23 |
5 |
0.02 |
mmu-miR-290-5p |
mmu04060: Cytokine-cytokine receptor interaction |
IL13RA1, IL18R1, CD40, IFNGR2, CXCL12, ACVR1B, CSF2RB |
7 |
0.001 |
mmu-miR-290-5p |
mmu04666: Fc gamma R-mediated phagocytosis |
MARCKS, AKT1 |
2 |
0.01 |
mmu-miR-290-5p |
mmu04520: Adherens junction |
LMO7, ERBB2, PTPRB, LEF1, INSR, SSX2IP, PVRL3 |
7 |
1.18E-06 |
mmu-miR-290-5p |
mmu04310: Wnt signaling pathway |
LEF1, CAMK2G, PLCB1, AXIN2 |
4 |
3.62E-04 |
mmu-miR-290-5p |
mmu04360: Axon guidance |
ROBO1, L1CAM, SEMA5B, CXCL12 |
4 |
0.001 |
mmu-miR-290-5p |
mmu04110: Cell cycle |
SMC3, MCM5, GADD45A, CDC25A, TFDP1, HDAC2, RAD21, ORC5L |
8 |
0.007 |
mmu-miR-290-5p |
mmu04350: TGF-beta signaling pathway |
TFDP1 |
1 |
6.96E-06 |
mmu-miR-290-5p |
mmu04510: Focal adhesion |
XIAP, ERBB2, AKT1 |
3 |
0.018 |
mmu-miR-203 |
mmu04630: Jak-STAT signaling pathway |
IL24, CNTFR, IL22RA2, CCND1, SOCS3, AKT2, IL12B |
7 |
0.01 |
mmu-miR-203 |
mmu04010: MAPK signaling pathway |
CACNA2D1, MAP3K13, DUSP5, MAP4K3, STK3, NLK, AKT2, ATF2, PDGFRA, RAP1A, MAPT, MAP3K1, PPM1B, FGF7, CRK, PRKCA |
16 |
0.02 |
mmu-miR-203 |
mmu04060: Cytokine-cytokine receptor interaction |
MET, IL24, CNTFR, ACVR2A, IL22RA2, VEGFA, XCL1, PDGFRA, IL12B |
9 |
0.001 |
mmu-miR-203 |
mmu04666: Fc gamma R-mediated phagocytosis |
PLD2, AKT2, DNM1L, PPAP2B, CRK, VAV3, PRKCA |
7 |
0.01 |
mmu-miR-203 |
mmu04520: Adherens junction |
MET, NLK, SRC, PTPRB, SNAI2 |
5 |
1.18E-06 |
mmu-miR-203 |
mmu04310: Wnt signaling pathway |
SFRP2, CCND1, NLK, APC, CSNK1A1, CUL1, PRKCA |
7 |
3.62E-04 |
mmu-miR-203 |
mmu04360: Axon guidance |
MET, ABL1, SEMA3A, SEMA6A, SEMA5A |
5 |
0.001 |
mmu-miR-203 |
mmu04110: Cell cycle |
YWHAQ, CCND1, ABL1, SKP2, CUL1 |
5 |
0.007 |
mmu-miR-203 |
mmu04350: TGF-beta signaling pathway |
ACVR2A, ID2, BMP5, CUL1, ID4 |
5 |
6.96E-06 |
mmu-miR-203 |
mmu04510: Focal adhesion |
MET, PXN, CCND1, VEGFA, PPP1C, SRC, PDGFRA, RAP1A, RAPGEF1, TNC, COL4A4, CAV1, CRK, VAV3, PRKCA |
15 |
0.018 |
mmu-miR-145 |
mmu04630: Jak-STAT signaling pathway |
MYC, STAM, STAT4, SOCS7 |
4 |
0.01 |
mmu-miR-145 |
mmu04010: MAPK signaling pathway |
MAP3K3, HSPA1L, PPP3CA, DUSP4, MYC, RASA2, RAPGEF2, FLNB, DUSP6, TGFBR2, MAP4K4, CRKL |
12 |
0.02 |
mmu-miR-145 |
mmu04060: Cytokine-cytokine receptor interaction |
FLT3L, TNFRSF11B, IL17RB, INHBB, ACVR1B, TGFBR2 |
6 |
0.001 |
mmu-miR-145 |
mmu04666:Fc gamma R-mediated phagocytosis |
ARF6, CFL2, LAT, ARPC5, CRKL |
5 |
0.01 |
mmu-miR-145 |
mmu04520: Adherens junction |
YES1, ERBB2, CTNND1, ACTG1, SMAD3, ACTB, TGFBR2 |
7 |
1.18E-06 |
mmu-miR-145 |
mmu04310: Wnt signaling pathway |
PPP3CA, FZD9, MYC, CTNNBIP1, SMAD3, SENP2, WNT5B |
7 |
3.62E-04 |
mmu-miR-145 |
mmu04360: Axon guidance |
PPP3CA, CFL2, SRGAP1, DPYSL2, SEMA3, EFNB3, SRGAP2, ABLIM2, SEMA6A, PLXNA2, SEMA3D |
11 |
0.001 |
mmu-miR-145 |
mmu04110: Cell cycle |
MCM5, MYC, SMAD3, CDK6, SFN, ORC2L |
6 |
0.007 |
mmu-miR-145 |
mmu04350: TGF-beta signaling pathway |
MYC, SMAD3, INHBB, TGFBR2, SMAD5 |
5 |
6.96E-06 |
mmu-miR-145 | mmu04510: Focal adhesion | ERBB2, ACTG1, FLNB, ACTB | 4 | 0.018 |