Table 3.
Top 20 term associations in category "non-overlap" that were identified by CroGO.
| MF Name | BP Name | Evidence |
|---|---|---|
| endopeptidase activator activity | proteasome core complex assembly | NEW |
| TFIIF-class binding TF activity | regulation of histone H3 K79 methylation | NEW |
| RNA-directed RNA polymerase activity | DNA-dependent transcriptional start site selection | LEXICAL |
| RNA-directed RNA polymerase activity | transcriptional start site selection at Pol II promoter | LEXICAL |
| single base insertion or deletion binding | chiasma assembly | REF [26] |
| double-strand/single-strand DNA junction binding | chiasma assembly | REF [26] |
| double-stranded telomeric DNA binding | gene conversion at mating-type locus, DNA double-strand break processing | NEW |
| G-quadruplex DNA binding | gene conversion at mating-type locus, DNA double-strand break processing | NEW |
| very long-chain fatty acid-CoA ligase activity | long-chain fatty-acyl-CoA metabolic process | REF [27] |
| very long-chain fatty acid-CoA ligase activity | fatty-acyl-CoA metabolic process | REF [27] |
| very long-chain fatty acid-CoA ligase activity | acyl-CoA metabolic process | REF [27] |
| single base insertion or deletion binding | meiotic heteroduplex formation | NEW |
| guanine/thymine mispair binding | chiasma assembly | NEW |
| TFIIE-class TF binding | negative regulation of ribosomal protein gene transcription from Pol II promoter in response to chemical stimulus | REF [28] |
| TFIIE-class binding TF activity | negative regulation of ribosomal protein gene transcription from Pol II promoter in response to chemical stimulus | REF [28] |
| Hsp90 protein binding | positive regulation of telomere maintenance via telomerase | NEW |
| Hsp90 protein binding | positive regulation of telomere maintenance | REF [29] |
| Hsp90 protein binding | positive regulation of homeostatic process | REF [30] |
| aldehyde dehydrogenase activity | beta-alanine metabolic process | REF [31] |
| aldehyde dehydrogenase activity | beta-alanine biosynthetic process | REF [31] |
Top 20 term associations in category "non-overlap" that were identified by CroGO. In the list, 11 term associations are supported by the existing biological studies, 2 are supported by the lexical matching on term definition, and the rest 7 are new conceptual connections that cannot be found in any literature. None of the term associations can be identified by the VSM or ASR based measures.