Table 1.
Targets of known human viral miRNA are enriched for KEGG Pathways.
| KEGG Pathway Name | Total (135) | HSV1 (25) | HSV2 (24) | EBV (44) | CMV (17) | KSHV (25) |
|---|---|---|---|---|---|---|
| Cancer | 10(27) | 2(3) | 2(4) | 2 (3) | 1(6) | 3(11) |
| ErbB signaling pathway | 9 | 3 | 2 | 4 | 0 | 0 |
| Axon guidance | 7 | 3 | 1 | 1 | 0 | 2 |
| Melanogenesis | 6 | 2 | 2 | 0 | 1 | 1 |
| MAPK signaling pathway | 5 | 0 | 1 | 0 | 1 | 3 |
| GnRH signaling pathway | 4 | 0 | 0 | 0 | 1 | 3 |
| Wnt signaling pathway | 4 | 1 | 0 | 1 | 1 | 1 |
Individual viral miRNAs target human genes that are enriched for KEGG pathways, and multiple viruses target the same pathways even across virus families. We list the pathways that were represented multiple times with a FDR of 1%. The name of the virus and number of known miRNA used for analysis is supplied as the header; the values indicate the number of miRNA that are enriched for the pathway listed. Cancer pathways were aggregated into one category and the value indicates the number of miRNA that are enriched for a cancer-related pathway and in parenthesis is the total number of cancer pathways enriched.