Table 3.
Human miRNA targets are enriched for KEGG Pathways and GO terms, and multiple viruses target the same pathways even across virus families.
| KEGG Pathway | adeno/herpes/pox | Gene Ontology | adeno/herpes/orf | ||
|---|---|---|---|---|---|
| #miRNA | # virus | #miRNA | # virus | ||
| Biosynthesis of steroids | 2/1/0 | 2/1/0 | Cytoplasmic microtubule | 0/9/0 | 0/3/0 |
| Glycerolipid metabolism | 0/3/1 | 0/3/1 | Microtubule binding | 0/9/0 | 0/2/0 |
| ErbB signaling pathway | 7/0/0 | 4/0/0 | Kinase binding | 0/8/0 | 0/2/0 |
| Regulation of autophagy | 2/1/0 | 2/1/0 | Cytoplasmic vesicle membrane | 4/4/0 | 4/3/0 |
| Hedgehog signaling pathway | 0/3/0 | 0/2/0 | Inner ear morphogenesis | 0/8/0 | 0/2/0 |
| Axon guidance | 3/5/0 | 2/3/0 | Multicellular organismal development | 0/7/0 | 0/5/0 |
| Antigen processing and presentation | 3/6/3 | 2/4/1 | Transferrin transport | 4/3/0 | 4/2/0 |
| Long-term potentiation | 0/4/0 | 0/2/0 | Protein autophosphorylation | 5/2/0 | 5/1/0 |
| GnRH signaling pathway | 2/2/0 | 2/2/0 | Protein serine/threonine kinase activity | 0/5/1 | 0/5/1 |
| Cancer | 3/17/7 | 2/6/1 | Extracell-glutamate-gated ion channel activity | 5/1/0 | 4/1/0 |
| Voltage-gated ion channel activity | 1/5/0 | 1/3/0 | |||
| Synaptic transmission | 1/5/0 | 1/4/0 | |||
| Histone methylation | 0/4/2 | 0/3/1 | |||
| Canonical Wnt Receptor signaling pathway | 0/4/2 | 0/3/1 | |||
We list the pathways that were represented multiple times with an FDR of 10%. The numbers separated by a slash correspond to adeno, herpes and orf families of viruses.