Figure 5. Histone switches in AML stem vs. progenitor cells. (A) Number of genes in each histone category in stem and progenitor AML cells. Arrows point to the histone status in progenitor cells by baseline histone status in stem cells. Thus, of 13617 K4 only promoters in stem cells, 83% remain K4 only in progenitor cells and 17% switch to other histone status. (B) Graphical representation of data shown in (A). (C) Pathway analysis for the genes that are bivalent in stem cells and switch to K4 only or K27 only in progenitor cells.