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. 2013 Jan 21;8(1):e50625. doi: 10.1371/journal.pone.0050625

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© 2013 Rish et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(a) Activations vs. normalized degrees; (b) clustering coefficients, strength, absolute strength, positive strength, and local efficiency of each voxel; (c) 200,000 randomly selected pairwise correlations. The null hypothesis for each feature assumes no difference between the schizophrenic vs normal groups. P-values of the features are sorted in ascending order and plotted vs FDR baseline; FDR test select voxels with , - false-positive rate, - the index of a p-value in the sorted sequence, N - the total number of voxels. Note that graph-based features yield a large number of highly-significant (very low) p-values, staying far below the FDR cut-off line, while only a few voxels survive FDR in case of (unnormalized) activation maps in panel (a): 7 and 2 voxels in activation maps 1 (contrast “FrenchNative – Silence”) and 6 (“FrenchNative”), respectively, while the rest of the activation maps do not survive the FDR correction at all.

Inline graphic — (a) Activations vs. normalized degrees; (b) clustering coefficients, strength, absolute strength, positive strength, and local efficiency of each voxel; (c) 200,000 randomly selected pairwise correlations. The null hypothesis for each feature assumes no difference between the schizophrenic vs normal groups. P-values of the features are sorted in ascending order and plotted vs FDR baseline; FDR test select voxels with , - false-positive rate, - the index of a p-value in the sorted sequence, N - the total number of voxels. Note that graph-based features yield a large number of highly-significant (very low) p-values, staying far below the FDR cut-off line, while only a few voxels survive FDR in case of (unnormalized) activation maps in panel (a): 7 and 2 voxels in activation maps 1 (contrast “FrenchNative – Silence”) and 6 (“FrenchNative”), respectively, while the rest of the activation maps do not survive the FDR correction at all.