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. 2013 Jan 21;8(1):e54346. doi: 10.1371/journal.pone.0054346

Figure 8. Effect of TP421 treatment on DNA damage and apoptosis induction.

Figure 8

(A) BxPC-3 and MIA PaCa-2 cells treated with increasing concentrations of TP421 for 12–48 h were probed for the DNA damage marker phospho-H2A.X (S139). (B) MIA PaCa-2 cells treated with TP421 were probed for caspase activation and PARP-1 cleavage. (C) The effect of TP421 treatment on Bcl-2 and survivin levels was analyzed in MIA PaCa-2 cells.