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. 2013 Jan 21;8(1):e54509. doi: 10.1371/journal.pone.0054509

Figure 4. Cell survival signaling through proHB-EGF.

Figure 4

The cell survival activity of proHB-EGF was tested by measuring caspase activation. NUGC-3 cells were seeded into a spheroid culture plate in the presence of 1% serum. After a 1-d incubation period, the cells were treated with Y-142 and cultured for 1 d. Caspase activation was measured by Caspase-Glo 3/7. Control IgG, white square; Y-142, black square; Y-073, black circle. The data points represent the mean ± SD of values acquired in triplicate.