Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Jan 21;200(2):131–140. doi: 10.1083/jcb.201210007

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2013 McNally

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 2. — How to center a spindle. Schematic diagram of a metaphase HeLa cell where the spindle oscillates along its pole–pole axis to maintain a centered position to allow symmetric cytokinesis. (A) When the left spindle pole is close to the cortex, Plk1 on the pole (red) causes dynein (green) to dissociate from LGN–NuMA complexes (purple; human homologues of GPR-1,2/LIN-5). (B and C) The spindle moves to the right because of the higher concentration of LGN–NuMA–dynein complexes on the right cortex. When chromosomes are close to the cortex as in A, the GTP-Ran gradient from the chromosomes causes dissociation of LGN/NuMA from the cortex. This second system centers the spindle in the axis perpendicular to the pole–pole axis.