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. 2013 Jan 21;8(1):e54463. doi: 10.1371/journal.pone.0054463

Figure 5. Intra-LA infusion of garcinol impairs fear memory consolidation and the consolidation of training-related neural plasticity in the LA.

Figure 5

(a) Rats were given two baseline AEFP recording sessions on separate days followed by fear conditioning with three tone-pip-shock pairings followed 1 hr later by intra-LA infusion of either vehicle (n = 8) or garcinol (500 ng/side; n = 7). Rats in each group were then tested for STM and LTM 3 and 21 hrs later while AEFPs were recorded from the LA. (b) Mean (± SEM) percent freezing during the STM and LTM tests in vehicle and garcinol-infused groups. (c) Mean (± SEM) percent of change in AEFP amplitude during the STM and LTM tests in vehicle and garcinol-infused rats, relative to baseline. *p<0.05 relative to vehicle-infused controls. (d) Representative AEFPs recorded from the LA for each group during baseline (light gray trace), STM and LTM sessions (darker traces). Scale bar  = 10 µV, 5 ms. (e) Electrode placements for rats infused with either vehicle (black circles) or garcinol (gray circles).