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. 2013 Jan 21;8(1):e54463. doi: 10.1371/journal.pone.0054463

Figure 7. Intra-LA infusion of garcinol in the absence of fear memory retrieval has no effect on fear memory reconsolidation or memory-related neural plasticity in the LA.

Figure 7

(a) Rats were given two baseline AEFP recording sessions on separate days followed by fear conditioning with three tone-pip-shock pairings. Twenty four hrs following training rats were given a ‘no-reactivation’ session followed by infusion of vehicle (n = 7) or garcinol (500 ng/side; n = 6). Rats in each group were then tested for ‘PR’-STM and ‘PR’-LTM 3 and 21 hrs later while AEFPs were recorded from the LA. (b) Memory retrieval data for the vehicle and garcinol-infused groups. (c) Mean (± SEM) percent freezing during the ‘PR’-STM and ‘PR’-LTM tests in vehicle and garcinol-infused groups. (d) Mean (± SEM) percent of change in AEFP amplitude during the ‘PR’-STM and ‘PR’-LTM tests in vehicle and garcinol-infused rats, relative to baseline. *p<0.05 relative to vehicle-infused controls. (e) Representative AEFPs recorded from the LA for each group during baseline (light gray trace), ‘PR’-STM and ‘PR’-LTM sessions (darker traces). Scale bar  = 10 µV, 5 ms. (f) Electrode placements for rats infused with either vehicle (black circles) or garcinol (gray circles).