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. 2013 Jan 21;8(1):e54263. doi: 10.1371/journal.pone.0054263

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© 2013 Munang'andu et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A) Virus neutralization (VN) titers generated from TAT, TTT, PAA and PTA inactivated vaccines against the TAT challenge strain at 10 wpv shows significantly higher VN titer for TAT over PAA and PTA groups (p<0.05). The TTT group was not different from any other group. N = 12; ±SEM. B) Antibody response by ELISA at 10 wpv against TAT antigen coat for the TAT, TTT, PAA and PTA vaccines. TAT is different from all other groups. N = 12; ±SEM. C) VN titers of serum from fish vaccinated with different vaccines at 10 wpv. Each group of vaccine was tested against the corresponding vaccine antigen. As can be seen the trend is similar to what is seen in B) but with lower antibody levels against corresponding antigen. N = 12; ±SEM.