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. 2007 Jun;3(2):73–81. doi: 10.1007/BF03160912

Case files of the university of cincinnati fellowship in medical toxicology: Two patients with acute lethal occupational exposure to hydrogen sulfide

Michael A Policastro 1,✉, Edward J Otten 2,3
PMCID: PMC3550088  PMID: 18072164

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There was no outside funding of any kind used in this study.

References

  • 1.Smith RP, et al. Hydrogen sulfide.National Research Council on Medical and Biological Effects of Environmental Pollutants.1979; 1–183.
  • 2.Mitchell CW, Davenport SJ. Hydrogen sulfide literature. Public Health Reports. 1942;30:1–13. [Google Scholar]
  • 3.Hugo V. Les Miserables. Boston: Little Brown and Company; 1887. [Google Scholar]
  • 4.Burnett WW, King EG, Grace M, Hall WF. Hydrogen sulfide poisoning: Review of 5 years’ experience. Can Med Assoc J. 1977;117:1277–1280. [PMC free article] [PubMed] [Google Scholar]
  • 5.Fuller DC, Suruda AJ. Occupationally related hydrogen sulfide deaths in the United States from 1984 to 1994. J Occup Environ Med. 2000;42:939–942. doi: 10.1097/00043764-200009000-00019. [DOI] [PubMed] [Google Scholar]
  • 6.Valent F, et al. Fatal work-related inhalation of harmful substances in the united states. Chest. 2002;121:969–975. doi: 10.1378/chest.121.3.969. [DOI] [PubMed] [Google Scholar]
  • 7.Hendrickson RG, et al. Co-worker fatalities from hydrogen sulfide. American Journal of Industrial Medicine. 2004;45:346–350. doi: 10.1002/ajim.10355. [DOI] [PubMed] [Google Scholar]
  • 8.Lai MW, Klein-Schwartz W, Rodgers GC, Abrams JY, Haber DA, Bronstein AC, Wruk KM. 2005 Annual Report of the American Association of Poison Control Centers’ National Poisoning and Exposure Database. Clin Toxicol (Phila). 2006;44:803–932. doi: 10.1080/15563650600907165. [DOI] [PubMed] [Google Scholar]
  • 9.Deng JF. Hydrogen sulfide. In: Sullivan JB, Krieger GR, editors. Clinical Environmental Health and Toxic Exposures. Philadelphia, Lippincott: Williams, and Wilkins; 2001. pp. 716–721. [Google Scholar]
  • 10.Langford NJ, Ferner RE. Episodes of environmental poisoning worldwide. Occup Environ Med. 2002;59:855–860. doi: 10.1136/oem.59.12.855. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 11.UNEP Production and Consumption Branch APELL (Awareness and Preparedness for Emergencies on a Local Level) Disaster Database. [accessed 19 Jan2007]. http://www/unep.fr/ pc/apell/disasters/database/disastersdatabase.asp.
  • 12.Boden C. China offers $3.6 million to gas disaster survivors.Seattle Times.2004.
  • 13.Beauchamp RO, Bus JS, Pop JA, Boreiko CJ, Andjelkovich DA. A critical review of the literature on hydrogen sulfide toxicity. Critical Reviews in Toxicology. 1984;13:25–97. doi: 10.3109/10408448409029321. [DOI] [PubMed] [Google Scholar]
  • 14.Council SR. Toxicology profile for hydrogen sulfide (update).US Department of Health and Human Services. Agency for Toxic Substance and Disease Registry.2006; 1–201, Appendices A-201.
  • 15.Snyder JW, Safir EF, Summerville GP, Middleberg RA. Occupational fatality and persistent neurological sequelae after mass exposure to hydrogen sulfide. Am J Emerg Med. 1995;13:199–203. doi: 10.1016/0735-6757(95)90094-2. [DOI] [PubMed] [Google Scholar]
  • 16.Svendsen K. Hydrogen sulfide. The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals and The Dutch Expert Committee On Occupational Standards.2001; 1–31.
  • 17.Chou S. United Nations Environmental Programme, the International Labor Organization, and The World Health Organization. Hydrogen sulfide: Human health aspects; 2003. [Google Scholar]
  • 18.Holstege CP, Ison GE, Kirk MA. Cyanide and hydrogen sulfide. In: Goldfrank LR, Flomenbaum NE, Lewin NA, Hoffman RS, Howland MA, Nelson LS, editors. Goldfrank’s toxicologic emergencies. New York: The McGraw-Hill Companies, Inc; 2006. pp. 1718–1721. [Google Scholar]
  • 19.Milby TH, Baselt RC. Hydrogen sulfide poisoning: Clarification of some controversial issues. Am J Ind Med. 1999;35:192–195. doi: 10.1002/(SICI)1097-0274(199902)35:2<192::AID-AJIM11>3.0.CO;2-C. [DOI] [PubMed] [Google Scholar]
  • 20.Woodall GM, Smith RL, Granville GC. Proceedings of the hydrogen sulfide health research and risk assessment symposium October 31-November 2, 2000. Inhal Toxicol. 2005;17:593–639. doi: 10.1080/08958370591000618. [DOI] [PubMed] [Google Scholar]
  • 21.Leiken K. Hydrogen sulfide. In: Ford M, Delaney KA, Ling L, Erickson T, editors. Clinical Toxicology. Philadelphia, WB: Saunders; 2001. pp. 712–715. [Google Scholar]
  • 22.Lambert, Timothy W, Goodwin, Verona M, Stefani D, Strosher L. Hydrogen sulfide (h2s) and sour gas effects on the eye. A historical perspective. Science of the Total Environment. 2006;367:1–22. doi: 10.1016/j.scitotenv.2006.01.034. [DOI] [PubMed] [Google Scholar]
  • 23.Belley R, et al. Hyperbaric oxygen therapy in the management of two cases of hydrogen sulfide toxicity from liquid manure. CJEM. 2005;7:257–261. doi: 10.1017/s1481803500014408. [DOI] [PubMed] [Google Scholar]
  • 24.Dorman DC, Moulin FJ, McManus BE, Mahle KC, James RA, Struve MF. Cytochrome oxidase inhibition induced by acute hydrogen sulfide inhalation: Correlation with tissue sulfide concentrations in the rat brain, liver, lung, and nasal epithelium. Toxicol Sci. 2002;65:18–25. doi: 10.1093/toxsci/65.1.18. [DOI] [PubMed] [Google Scholar]
  • 25.Hall AH, Rumack BH. Hydrogen sulfide poisoning: An antidotal role for sodium nitrite? Vet Hum Toxicol. 1997;39:152–154. [PubMed] [Google Scholar]
  • 26.Stine RJ, Slosberg B, Beacham BE. Hydrogen sulfide intoxication. A case report and discussion of treatment. Ann Intern Med. 1976;85:756–758. doi: 10.7326/0003-4819-85-6-756. [DOI] [PubMed] [Google Scholar]
  • 27.Tvedt B, Skyberg K, Aaserud O, Hobbesland A, Mathiesen T. Brain damage caused by hydrogen sulfide: A follow-up study of six patients. Am J Ind Med. 1991;20:91–101. doi: 10.1002/ajim.4700200109. [DOI] [PubMed] [Google Scholar]
  • 28.Abe K, Kimura H. The possible role of hydrogen sulfide as an endogenous neuromodulator. J Neurosci. 1996;16:1066–1071. doi: 10.1523/JNEUROSCI.16-03-01066.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 29.Dello Russo C, Tringali G, Ragazzoni E, Maggiano N, Menini E, Vairano M, Preziosi P, Navarra P. Evidence that hydrogen sulphide can modulate hypothalamo-pituitary-adrenal axis function: In vitro and in vivo studies in the rat. J Neuroendocrinol. 2000;12:225–233. doi: 10.1046/j.1365-2826.2000.00441.x. [DOI] [PubMed] [Google Scholar]
  • 30.Leffler CW, Parfenova H, Jaggar JH, Wang R. Carbon monoxide and hydrogen sulfide: Gaseous messengers in cerebrovascular circulation. J Appl Physiol. 2006;100:1065–1076. doi: 10.1152/japplphysiol.00793.2005. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 31.Kamoun P, Belardinelli MC, Chabli A, Lallouchi K, Chadefaux-Vekemans B. Endogenous hydrogen sulfide overproduction in down syndrome. Am J Med Genet A. 2003;116:310–311. doi: 10.1002/ajmg.a.10847. [DOI] [PubMed] [Google Scholar]
  • 32.Kilburn KH. Effects of hydrogen sulfide on neurobehavioral function. South Med J. 2003;96:639–646. doi: 10.1097/01.SMJ.0000072361.86796.56. [DOI] [PubMed] [Google Scholar]
  • 33.Tang G, Wu L, Liang W, Wang R. Direct stimulation of k(atp) channels by exogenous and endogenous hydrogen sulfide in vascular smooth muscle cells. Mol Pharmacol. 2005;68:1757–1764. doi: 10.1124/mol.105.017467. [DOI] [PubMed] [Google Scholar]
  • 34.Kuschner WG, Blanc PD. Gases and other inhalants. In: LaDou J, editor. Occupational and environmental medicine. International: McGraw-Hill; 1997. pp. 572–583. [Google Scholar]
  • 35.Curry SC, Gerkin RD. A patient with sulfhemoglobin? Ann Emerg Med. 1987;16:828–830. [PubMed] [Google Scholar]
  • 36.Park CM, Nagel RL. Sulfhemoglobinemia. Clinical and molecular aspects. N Engl J Med. 1984;310:1579–1584. doi: 10.1056/NEJM198406143102407. [DOI] [PubMed] [Google Scholar]
  • 37.Park CM, Nagel RL, Blumberg WE, Peisach J, Magliozzo RS. Sulfhemoglobin. Properties of partially sulfurated tetramers. J Biol Chem. 1986;261:8805–8810. [PubMed] [Google Scholar]
  • 38.Lu HC, Shih RD, Marcus S, Ruck B, Jennis T. Pseudomethemoglobinemia: A case report and review of sulfhemoglobinemia. Arch Pediatr Adolesc Med. 1998;152:803–805. doi: 10.1001/archpedi.152.8.803. [DOI] [PubMed] [Google Scholar]
  • 39.Wu C, Kenny MA. A case of sulfhemoglobinemia and emergency measurement of sulfhemoglobin with an osm3 co-oximeter. Clin Chem. 1997;43:162–166. [PubMed] [Google Scholar]
  • 40.Zijistra WG, Buurama A, Zwart A. A performance of an automated six wavelenght photometer (radiometer osm3) for routine measurement of hemoglobin deratives. Clin Chem. 1998;34:149–152. [PubMed] [Google Scholar]
  • 41.Aravindhan N, Chisholm DG. Sulfhemoglobinemia presenting as pulse oximetry desaturation. Anesthesiology. 2000;93:883–884. doi: 10.1097/00000542-200009000-00040. [DOI] [PubMed] [Google Scholar]
  • 42.Brandenburg RO, Smith HL. Sulfhemoglobinemia; a study of 62 clinical cases. Am Heart J. 1951;42:582–588. doi: 10.1016/0002-8703(51)90153-6. [DOI] [PubMed] [Google Scholar]
  • 43.Noor M, Beutler E. Acquired sulfhemoglobinemia. An underreported diagnosis? West J Med. 1998;169:386–389. [PMC free article] [PubMed] [Google Scholar]
  • 44.Peters JW. Hydrogen sulfide poisoning in a hospital setting. JAMA. 1981;246:1588–1589. doi: 10.1001/jama.246.14.1588. [DOI] [PubMed] [Google Scholar]
  • 45.Hoidal CR, Hall AH, Robinson MD, Kulig K, Rumack BH. Hydrogen sulfide poisoning from toxic inhalations of roofing asphalt fumes. Ann Emerg Med. 1986;15:826–830. doi: 10.1016/S0196-0644(86)80383-3. [DOI] [PubMed] [Google Scholar]
  • 46.Haggard, Howard W. The toxicology of hydrogen sulphide. The Journal of Industrial Hygiene and Toxicology. 1925;7:113–121. [Google Scholar]
  • 47.Agency UEP. Toxicology review of hydrogen sulfide. In support of summary information of the integrated risk information systems 2003.
  • 48.Knight LD, Presnell SE. Death by sewer gas: Case report of a double fatality and review of the literature. Am J Forensic Med Pathol. 2005;26:181–185. [PubMed] [Google Scholar]
  • 49.Kage S, Ikeda H, Ikeda N, Tsujita A, Kudo K. Fatal hydrogen sulfide poisoning at a dye works. Leg Med (Tokyo). 2004;6:182–186. doi: 10.1016/j.legalmed.2004.04.004. [DOI] [PubMed] [Google Scholar]
  • 50.Kage S, Takekawa K, Kurosaki K, Imamura T, Kudo K. The usefulness of thiosulfate as an indicator of hydrogen sulfide poisoning: Three cases. Int J Legal Med. 1997;110:220–222. doi: 10.1007/s004140050071. [DOI] [PubMed] [Google Scholar]
  • 51.Nikkanen HE, Burns MM. Severe hydrogen sulfide exposure in a working adolescent. Pediatrics. 2004;113:927–929. doi: 10.1542/peds.113.4.927. [DOI] [PubMed] [Google Scholar]
  • 52.Tan WH, Eichler FS, Hoda S, Lee MS, Baris H, Hanley CA, Grant PE, Krishnamoorthy KS, Shih VE. Isolated sulfite oxidase deficiency: A case report with a novel mutation and review of the literature. Pediatrics. 2005;116:757–766. doi: 10.1542/peds.2004-1897. [DOI] [PubMed] [Google Scholar]
  • 53.Chaturvedi AK, Smith DR, Canfield DV. A fatality caused by accidental production of hydrogen sulfide. Forensic Sci Int. 2001;123:211–214. doi: 10.1016/S0379-0738(01)00552-7. [DOI] [PubMed] [Google Scholar]
  • 54.Wallace KB, Starkov AA. Mitochondrial targets of drug toxicity. Annu Rev Pharmacol Toxicol. 2000;40:353–388. doi: 10.1146/annurev.pharmtox.40.1.353. [DOI] [PubMed] [Google Scholar]
  • 55.Belley R, Bernard N, Cote M, Pacquet F, Poitras J. Hyperbaric oxygen therapy in the management of two cases of hydrogen sulfide toxicity from liquid manure. Can J Emer Med. 2005;7:257–261. doi: 10.1017/s1481803500014408. [DOI] [PubMed] [Google Scholar]
  • 56.Osbern LN, Crapo RO. Dung lung: A report of toxic exposure to liquid manure. Ann Intern Med. 1981;95:312–314. doi: 10.7326/0003-4819-95-3-312. [DOI] [PubMed] [Google Scholar]
  • 57.Osborn HH, Henry G, Wax P, Hoffman R, Howland MA. Theophylline toxicity in a premature neonate—elimination kinetics of exchange transfusion. J Toxicol Clin Toxicol. 1993;31:639–644. doi: 10.3109/15563659309025767. [DOI] [PubMed] [Google Scholar]
  • 58.Ravizza AG, Carugo D, Cerchiari EL, Cantadore R, Bianchi GE. The treatment of hydrogen sulfide intoxication: Oxygen versus nitrites. Vet Hum Toxicol. 1982;24:241–242. [PubMed] [Google Scholar]
  • 59.Whitcraft DD, Bailey TD, Hart GB. Hydrogen sulfide poisoning treated with hyperbaric oxygen. J Emerg Med. 1985;3:23–25. doi: 10.1016/0736-4679(85)90215-X. [DOI] [PubMed] [Google Scholar]
  • 60.Nelson K, Robinson DL. A case review: Near fatal residential hydrogen sulfide exposure. Air Med J. 2002;21:46–48. doi: 10.1016/S1067-991X(02)70040-0. [DOI] [PubMed] [Google Scholar]
  • 61.Smith RP. Cobalt salts: Effects in cyanide and sulfide poisoning and on methemoglobinemia. Toxicol Appl Pharmacol. 1969;15:505–516. doi: 10.1016/0041-008X(69)90052-0. [DOI] [PubMed] [Google Scholar]
  • 62.Smilkstein MJ, Bronstein AC, Pickett HM, Rumack BH. Hyperbaric oxygen therapy for severe hydrogen sulfide poisoning. J Emerg Med. 1985;3:27–30. doi: 10.1016/0736-4679(85)90216-1. [DOI] [PubMed] [Google Scholar]
  • 63.Danielson C, Houseworth J, Skipworth E, Smith D, McCarthy L, Nanagas K. Arsine toxicity treated with red blood cell and plasma exchanges. Transfusion. 2006;46:1576–1579. doi: 10.1111/j.1537-2995.2006.00931.x. [DOI] [PubMed] [Google Scholar]
  • 64.Golden PJ, Weinstein R. Treatment of high-risk, refractory acquired methemoglobinemia with automated red blood cell exchange. J Clin Apher. 1998;13:28–31. doi: 10.1002/(SICI)1098-1101(1998)13:1<28::AID-JCA6>3.0.CO;2-B. [DOI] [PubMed] [Google Scholar]
  • 65.Gorlin JB. Therapeutic plasma exchange and cytapheresis in pediatric patients. Transfus Sci. 1999;21:21–39. doi: 10.1016/S0955-3886(99)00064-8. [DOI] [PubMed] [Google Scholar]
  • 66.Manikian A, Stone S, Hamilton R, Foltin G, Howland MA, Hoffman RS. Exchange transfusion in severe infant salicylism. Vet Hum Toxicol. 2002;44:224–227. [PubMed] [Google Scholar]
  • 67.McLeod BC. The technique of therapeutic apheresis. Removal of abnormal blood elements may succeed when all else fails. J Crit Illn. 1991;6:487–495. [PubMed] [Google Scholar]
  • 68.Perrin C, Debruyne D, Lacotte J, Laloum D, Bonte JB, Moulin M. Treatment of caffeine intoxication by exchange transfusion in a newborn. ACTA Paediatr Scand. 1987;76:769–781. doi: 10.1111/j.1651-2227.1987.tb10546.x. [DOI] [PubMed] [Google Scholar]
  • 69.Tauberger G, Karzel K, Roezel V. [the efficacy of blood exchange transfusions in the treatment of acute cyanide poisoning (author’s transl)] Arch Toxicol. 1974;32:189–197. doi: 10.1007/BF00318433. [DOI] [PubMed] [Google Scholar]
  • 70.Valbonesi M, Bruni R. Clinical application of therapeutic erythrocytapheresis (tea) Transfus Sci. 2000;22:183–194. doi: 10.1016/S0955-3886(00)00042-4. [DOI] [PubMed] [Google Scholar]
  • 71.Reiffenstein RJ, Hulbert WC, Roth SH. Toxicology of hydrogen sulfide.Annual Review of Pharmacolgy and Toxicology.1992; 109–134. [DOI] [PubMed]
  • 72.Yant WP. Sulphide in industry occurrence, effects, and treatment. Am J Public Health Nations Health. 2000;20:598–608. doi: 10.2105/ajph.20.6.598. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 73.Done AK. The toxic emergency: Calling for help. Emerg Med. 1979;11:127–129. [PubMed] [Google Scholar]
  • 74.Duong TX, Suruda AJ, Maier LA. Interstitial fibrosis following hydrogen sulfide exposure. Am J Ind Med. 2001;40:221–224. doi: 10.1002/ajim.1091. [DOI] [PubMed] [Google Scholar]

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