Table 2.

Characteristics of study subjects.

Study sample	Baseline age				% Females	Sample size
	Mean	St. Dev.	Min	Max
TOTAL SAMPLE
	44.1	8.60	28	62	55.2%	5209
SHORT- VS. LONG-LIVED
Short-lived	44.0	8.35	28	62	42.4%	1801
Long-lived	47.8	6.58	37	62	85.0%	100
“UNHEALTHY” VS. “HEALTHY”
“unhealthy”	44.1	8.61	28	62	52.7%	4291
“healthy”	44.2	8.55	29	62	66.4%	788
CARRIERS OF DIFFERENT NUMBER OF PRO-SURVIVAL ALLELES
<14	42.0	7.32	30	61	54.4%	721
≥14	36.0	4.50	29	55	65.7%	750
CARRIERS (“E4”) AND NON-CARRIERS (“NOT E4”) OF THE APOE E4 ALLELE
e4	37.9	5.96	28	57	66.1%	277
not e4	37.6	5.66	29	57	63.1%	981
“UNHEALTHY” AMONG CARRIERS OF DIFFERENT NUMBER OF PRO-SURVIVAL ALLELES
“unhealthy”, <14	41.8	7.27	30	61	52.3%	637
“unhealthy”, ≥14	35.9	4.46	29	54	63.4%	658

Notes: Short-lived are those dying at ages below 75, long-lived are those with 100 longest life spans; see details in the text. “Unhealthy” are those who had onset of at least one of the three diseases (cancer, CVD, diabetes) during the follow-up period; “healthy” are those free of such disease during the follow-up period; see more details on calculations of average trajectories in “unhealthy” and “healthy” individuals in the text. Carriers of different numbers of pro-survival alleles are defined based on the 27 SNPs identified in Yashin et al. (2012c); see details on the selection procedure in the text.