Table 2.
Logistic regression models
| Variable | Unadjusted OR§ | 95% CI | p Value | Adjusted OR§ | 95% CI | p Value |
|---|---|---|---|---|---|---|
| Men | ||||||
| Age 60–69* | 2.55 | 2.4 to 2.72 | <0.0001 | 2.15 | 2.01 to 2.29 | <0.0001 |
| Age 70–79* | 2.32 | 2.19 to 2.45 | <0.0001 | 2.20 | 2.08 to 2.33 | <0.0001 |
| BMI <20† | 0.56 | 0.49 to 0.65 | <0.0001 | 0.60 | 0.52 to 0.70 | <0.0001 |
| BMI 25-<30† | 1.43 | 1.35 to 1.51 | <0.0001 | 1.30 | 1.23 to 1.38 | <0.0001 |
| BMI 30-<35† | 1.75 | 1.63 to 1.87 | <0.0001 | 1.46 | 1.36 to 1.57 | <0.0001 |
| BMI 35+† | 2.30 | 2.07 to 2.55 | <0.0001 | 1.73 | 1.55 to 1.93 | <0.0001 |
| Hypertension | 1.17 | 1.11 to 1.22 | <0.0001 | 1.24 | 1.18 to 1.3 | <0.0001 |
| Heart Failure | 1.34 | 1.27 to 1.41 | <0.0001 | 1.41 | 1.33 to 1.49 | <0.0001 |
| LVEF | 2.09 | 1.86 to 2.35 | <0.0001 | 1.72 | 1.52 to 1.94 | <0.0001 |
| Diabetes | 1.08 | 1.01 to 1.15 | <0.0001 | 0.94 | 0.88 to 1.00 | 0.05650 |
| Stroke/TIA | 1.15 | 1.07 to 1.23 | <0.0001 | 1.56 | 1.44 to 1.68 | <0.0001 |
| Dementia | 0.47 | 0.42 to 0.53 | <0.0001 | 0.59 | 0.52 to 0.66 | <0.0001 |
| Vascular Disease | 1.10 | 1.04 to 1.17 | 0.0006 | 1.10 | 1.03 to 1.16 | 0.00260 |
| Thromboembolism | 1.59 | 1.44 to 1.76 | <0.0001 | 1.59 | 1.44 to 1.77 | <0.0001 |
| HAS-BLED 2 | 0.82 | 0.78 to 0.87 | <0.0001 | 0.8 | 0.76 to 0.85 | <0.0001 |
| HAS-BLED 3 | 0.69 | 0.65 to 0.74 | <0.0001 | 0.612 | 0.57 to 0.66 | <0.0001 |
| HAS-BLED 4 | 0.55 | 0.5 to 0.61 | <0.0001 | 0.432 | 0.38 to 0.49 | <0.0001 |
| p | ||||||
| Goodness-of-fit‡ | 0.79 | |||||
| Women | ||||||
| Age 60–69* | 2.29 | 2.14 to 2.44 | <0.0001 | 1.95 | 1.82 to 2.10 | <0.0001 |
| Age 70–79* | 2.43 | 2.31 to 2.55 | <0.0001 | 2.29 | 2.17 to 2.41 | <0.0001 |
| BMI <20† | 0.63 | 0.58 to 0.70 | <0.0001 | 0.69 | 0.62 to 0.76 | <0.0001 |
| BMI 25-<30† | 1.35 | 1.28 to 1.43 | <0.0001 | 1.25 | 1.18 to 1.32 | <0.0001 |
| BMI 30-<35† | 1.55 | 1.45 to 1.66 | <0.0001 | 1.33 | 1.24 to 1.42 | <0.0001 |
| BMI 35+† | 1.96 | 1.81 to 2.13 | <0.0001 | 1.46 | 1.34 to 1.59 | <0.0001 |
| Hypertension | 1.14 | 1.09 to 1.19 | <0.0001 | 1.23 | 1.17 to 1.3 | <0.0001 |
| Heart Failure | 1.18 | 1.12 to 1.24 | <0.0001 | 1.28 | 1.21 to 1.35 | <0.0001 |
| LVEF | 1.82 | 1.58 to 2.11 | <0.0001 | 1.55 | 1.33 to 1.80 | <0.0001 |
| Diabetes | 1.00 | 0.94 to 1.07 | 0.93 | Not included in final model | ||
| Stroke/TIA | 1.16 | 1.08 to 1.24 | <0.0001 | 1.49 | 1.38 to 1.60 | <0.0001 |
| Dementia | 0.41 | 0.37 to 0.46 | <0.0001 | 0.51 | 0.46 to 0.57 | <0.0001 |
| Vascular disease | 0.96 | 0.89 to 1.03 | 0.22 | Not included in final model | ||
| Thromboembolism | 1.74 | 1.58 to 1.91 | <0.0001 | 1.72 | 1.56 to 1.90 | <0.0001 |
| HAS-BLED 2 | 0.85 | 0.81 to 0.9 | <0.0001 | 0.83 | 0.79 to 0.88 | <0.0001 |
| HAS-BLED 3 | 0.78 | 0.73 to 0.83 | <0.0001 | 0.71 | 0.66 to 0.76 | <0.0001 |
| HAS-BLED 4 | 0.61 | 0.55 to 0.68 | <0.0001 | 0.51 | 0.45 to 0.57 | <0.0001 |
| p | ||||||
| Goodness-of-fit‡ | 0.43 | |||||
*Age: reference group=Age 80+ years;
†BMI: reference group=BMI 20-<25;
‡Hosmer and Lemeshow goodness-of-fit test.
§ OR, unadjusted is crude OR adjusted for practice only, adjusted is OR from multivariable model adjusted for practice and all other variables included in the final model.