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. 2012 Mar 30;62(1):112–120. doi: 10.1136/gutjnl-2012-302529

Figure 4.

Figure 4

Combination therapy with PEGPH20 and gemcitabine inhibits tumour growth and significantly extends survival. (A) Tumour volume measurements from mice treated for 5 days with vehicle (V) (n=7), gemcitabine (G) (n=11), PEGPH20 (P) (n=10) and gemcitabine/PEGPH20 combination (P+G) (n=11) demonstrate cytostasis only in response to gemcitabine/PEGPH20 combination therapy. (B) Proliferation of pancreatic tumour cells in response to PEGPH20 treatment. A significant decrease in pancreatic tumour cell proliferation is observed 5 days after treatment with PEGPH20 and gemcitabine compared with gemcitabine alone. Mann–Whitney U test, *p=0.0432. (C) Kaplan–Meier survival curve for vehicle-treated (n=8, grey dotted line), gemcitabine-treated (n=15, black dotted line), PEGPH20-treated (n=12, green line) and gemcitabine/PEGPH20-treated (n=10, red line) KPC cohorts. A significant increase in survival was observed in gemcitabine/PEGPH20-treated mice relative to the gemcitabine-treated cohort. Log-rank ***p=0.0002, HR 0.06794. PH3, phospho-histone H3.