Table 5.
Characteristics of children with neurodevelopmental abnormalities
| Case | Mother's age | APS features | Pregnancy outcome | Pregnancy treatment | Gestational age (weeks) | Sex | Birth weight (g) | Clinical features | APL |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 32 | Obstetrical (IUGR/IUD) | Gestational diabetes | LWMH | 38 | M | 2790 | Autism | Negative |
| 2 | 23 | Obstetrical (RFL) | – | LWMH | 36 | M | 2500 | Hyperactive behaviour | Negative at birth; ACL IgG 12 U at 2 years |
| 3 | 44 | Obstetrical (RFL) | Gestational diabetes | LWMH-aspirin | 37 | F | 2900 | Feeding disorders, language delay, growth failure | Negative at birth; transient anti-β2GPI IgG 3–9 months |
| 4 | 33 | Obstetrical (IUGR/IUD) | IUGR | LWMH | 37 | F | 1570 | Axial hypotony, psychomotor delay | Negative |
ACL, anticardiolipin antibodies; anti-β2GPI, anti-β2 glycoprotein-I antibodies; APL, antiphospholipid antibodies; APS, antiphospholipid syndrome; F, female; IUD, intrauterine fetal death; IUGR, intrauterine growth restriction; LWMH, low-weight molecular heparin; M, male; RFL, recurrent fetal loss.