Table 3.
Histone acetylation.
| Modification | Modifier | Histone | Role in DNA repair | Reference |
|---|---|---|---|---|
| K5ac | TIP60 | H2AX | Helps in K119ub of H2AX and removal of H2AX from chromatin | Kusch et al. (2004), Ikura et al. (2007) |
| K36ac | CBP/p300 | H2AX | Recruits Ku during NHEJ | Deem et al. (2012) |
| K9ac, K14ac, K23ac K27ac | GCN5,CBP/p300 | H3 | Recruits SW1/SNF complex, promotes spreading of γ-H2AX domain and regulates ATM activity | Tamburini and Tyler (2005) |
| K18ac | GCN5,CBP/p300 | H3 | Regulates Ku protein recruitment during DSB repair | Ogiwara et al. (2011) |
| K56ac | GCN5,CBP/p300, RTT109 | H3 | Depletes after IR to promote NHEJ, enriches K56ac after HR and UV repair | Miller et al. (2010) |
| K5ac, K8ac, K12ac, K16ac | MOF, TIP60-TRRAP; CBP/p300 | H4 | Recruits DDR and repair proteins and recruits SW1/SNF nucleosome remodeling complex | Gupta et al. (2005, 2008), Sharma et al. (2010) |