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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: J Clin Rheumatol. 2013 Jan;19(1):19–29. doi: 10.1097/RHU.0b013e31827d8790

Figure 1. The most common mechanisms of therapeutic anti-inflammatory action of gouty arthritis drugs.

Figure 1

Colchicine, NSAIDs, and glucocorticoids act on many different molecular targets; the mechanisms displayed herein are the most likely targets for reduction of monosodium urate crystal-induced inflammation when these drugs are administered at the recommended therapeutic doses. Anti-IL-1, IL1-RA, and IL1-Trap therapies act specifically to block IL-1β.