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. 2012 Oct 12;131(2):395–405. doi: 10.1093/toxsci/kfs297

Fig. 2.

Fig. 2.

DCPA and its metabolites inhibit IL-2 secretion. Jurkat T cells were treated with (A) DCPA, (B) DCA, (C) 6OH-DCA, (D) NOH-DCA in the concentrations indicated on the figure. Additional treatment groups included a vehicle (veh) control and a no treatment (labeled “cells”). All experimental groups were stimulated with anti-CD3 and anti-CD28 for 24h as described in the Materials and Methods section. Supernatants were analyzed by standard ELISA methods to quantitate IL-2 secretion. Graphs are representative of three separate experiments, each performed in triplicate wells. Error bars reflect ± SEM and asterisks (*) indicate statistically significant results for all experimental units, p < 0.05 using ANOVA with a Student-Newman-Keuls post hoc test.