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Histology of control and NSC 710305–treated PCLS after a 24-h recovery period from 72-h exposures to NSC 710305. Untreated PCLS controls (A) show well-preserved lung morphology with minimal loss of cellularity. PCLS treated for 72h with NSC 710305 at 25μM (B), 50μM (C), and 100μM (D) show distortions in the alveolar architecture, nuclear shrinkage, and a progressive loss of cellularity, indicating continued cytotoxic effects of the drug (H&E staining, ×200 magnification).
