TABLE 2 .
Assessment of NSC 710305 Removal on Cytokine Levels at Exposure Concentrations That Caused Significant Increases Over Control Levels
| NSC 710305 | Time point | IL-1β | CINC | IL-4 | IL-5 | TNF-α | IFN-γ |
|---|---|---|---|---|---|---|---|
| 25μM | 72-h exposure | 99.1 | 1421.8 | 3.9 | 150.9 | 25.1 | 13.5 |
| 24-h recovery | 60.6 | 899.6 | 2.9 | 63.1 | 20.0 | 16.0 | |
| Δ | −38.6 | −522.2 | −1.0 | −87.8 | −5.1 | 2.5 | |
| % Change | −39 | −37 | −25 | −58 | −20 | 19 | |
| 50μM | 72-h exposure | 323.4 | 12623.1 | 11.6 | 317.0 | 61.0 | 34.6 |
| 24-h recovery | 479.4 | 17445.4 | 44.0 | 700.7 | 87.2 | 40.4 | |
| Δ | 156.0 | 4822.3 | 32.3 | 383.7 | 26.2 | 5.8 | |
| % Change | 48 | 38 | 278 | 121 | 43 | 17 | |
| 100μM | 72-h exposure | 1356.2 | 43908.0 | 43.0 | 1243.3 | 205.5 | 118.1 |
| 24-h recovery | 2925.8 | 91368.7 | 89.5 | 2004.8 | 372.8 | 232.0 | |
| Δ | 1569.6 | 47460.7 | 46.6 | 761.5 | 167.3 | 113.9 | |
| % Change | 116 | 108 | 108 | 61 | 81 | 96 |
All values are expressed as pg/mg protein except % Change (the % increase or decrease, relative to the 72-h value) measured after 24-h drug removal. Bold values indicate a reduction or increase of tissue cytokine levels, respectively.